Enantioselective alkenylation via nickel-catalyzed cross-coupling with organozirconium reagents.
نویسندگان
چکیده
A new family of organometallic compounds, organozirconium reagents, are shown to serve as suitable partners in cross-coupling reactions of (activated) secondary alkyl electrophiles. Thus, the first catalytic method for coupling secondary alpha-bromoketones with alkenylmetal reagents has been developed, specifically, a mild, versatile, and stereoconvergent carbon-carbon bond-forming process that generates potentially labile beta,gamma-unsaturated ketones with good enantioselectivity.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 132 14 شماره
صفحات -
تاریخ انتشار 2010